姓名:劉月陽
出生年月:1989年4月
學位:博士
專業:藥理學
職稱/職務:副教授
主要研究方向:
缺血性腦卒中的發病機制及藥物防治
累計發表文章10餘篇。主要研究成果以第一作者或共同第一作者發表于本領域知名期刊《Autophagy》、《Stroke》上。主持國家自然科學基金青年基金一項及遼甯省自然科學基金計劃重點項目一項。參與國家自然科學基金面上項目一項。2019年12月入選遼甯省百千萬人才工程項目“萬人層次”。2020年12月被評為沈陽市高層次人才“高級人才”。
主持及參與科研項目情況:
1.國家自然科學基金青年基金項目,81901222,運用CRISPR/Cas9轉基因小鼠研究GHRH-A調控神經發生在腦缺血-再灌注損傷中的作用及相關機制,2020/01-2022/12,20.5萬,主持,在研。
2.遼甯省自然科學基金計劃重點項目(省博士啟動),20180540063,運用Nestin-CreERT2:Td-Tomato雙轉基因小鼠考察MR-409對腦缺血後神經幹細胞的調節作用及相關機制,2018/09-2020/08,3萬,主持,結題。
3. 國家自然科學基金面上項目,81970357,AT1R介導的巨噬細胞功能失常在鹽敏感性高血壓血管胰島素抵抗中的作用機制研究,2020/01-2023/12,55萬,參與,在研。
發表文章情況:
1. Yueyang Liu, Xue Xue, Hantian Zhang, Xiaohang Che, Jing Luo, Ping Wang, Jiaoyan Xu, Zheng Xing, Linlin Yuan, Yinglu Liu, Xiaoxiao Fu, Dongmei Su, Shibo Sun, Hannan Zhang, Chunfu Wu*, Jingyu Yang*. Neuronal-targeted TFEB rescues dysfunction of the autophagy-lysosomal pathway and alleviates ischemic injury in permanent cerebral ischemia, 2019, Autophagy 15(3), 493-509. (IF: 9.77,中科院一區Top)
2. Yueyang Liu#, Xiaohang Che#, Haotian Zhang, Xiaoxiao Fu, Yang Yao, Luo Jun, Yu Yang, Ruiping Cai, Xiangnan Yu, Jingyu Yang*, Mingsheng Zhou*; Calpain1-mediated impairment of autophagic flux contributes to cerebral ischemia-induced neuronal damage, Stroke, 2021 May;52(5):1809-1821. (IF: 7.91, 中科院一區Top)
3. Yueyang Liu, Tianyu Zhang, Haotian Zhang, Linlin Yuan, Yinglu Liu, Hanlin Yang, Shibo Sun, Jingyu Yang*, Pseudoginsenoside-F11 attenuates cerebral ischemic injury via alleviating autophagic/lysosomal defects. CNS neuroscience & therapeutics, 2017, 23(7):567-579. (IF: 3.495,中科院二區)
4. Yueyang Liu#, Jun Luo#, Ruiping Cai, Junjie Zhang, Qian Xu, Yuangtong Tian, Mingsheng Zhou*. Macrophage Depletion Improves Endothelial Insulin Resistance and Protects against Cardiovascular Injury in Salt-Sensitive Hypertension. BioMed Research International, 2020, 2020 (IF: 3.411,中科院三區)
5. Xiaoxiao Fu, Yueyang Liu, Haonan Zhang, Xiangnan Yu, Xuemei Wang, Chunfu Wu, Jingyu Yang*. Pseudoginsenoside F11 ameliorates the dysfunction of the autophagy-lysosomal pathway by activating calcineurin-mediated TFEB nuclear translocation in neuron during permanent cerebral ischemia. Experimental Neurology. 2021, Jan 8;338:113598. (IF: 5.33,中科院二區)
6. Yongfeng Gao, Yueyang Liu, Xue Yang, Tianyu Zhang, Ying Hou, Pengwei Wang, Yinglu Liu, Linlin Yuan, Haotian Zhang, Chunfu Wu, Jingyu Yang. Pseudoginsenoside-F11 ameliorates thromboembolic stroke injury in rats by reducing thromboinflammation. Neurochem Int. 2021 Jun 24;105108.(IF:3.921,中科院二區)
7. Xiaohang Che; Jialing Cai; Yueyang Liu; Tianyu Xu; Jingyu Yang*; Chunfu Wu*;Oxytocin signaling in the treatment of drug addiction: Therapeutic opportunities and challenges, Pharmacology & Therapeutics, 2021, 223, 107820. (IF:12.31,中科院一區Top)
8. Ruiping Cai, Yun Hao, Yueyang Liu, Lei Huang, Yang Yao, and Ming-Sheng Zhou*. Tumor Necrosis Factor Alpha Deficiency Improves Endothelial Function and Cardiovascular Injury in Deoxycorticosterone Acetate/Salt-Hypertensive Mice. BioMed Research International. 2020, 2020. (IF:3.411,中科院三區)
9. Xuemei Chen, Nannan Wang, Yueyang Liu, Yinglu Liu, Tianyu Zhang, Lei Zhu, Chunfu Wu*, Jingyu Yang*. Yonkenafil: A novel phosphodiesterase type 5 inhibitor induces neuronal network potentiation by a cGMP-dependent Nogo-R axis in acute experimental stroke. Experimental Neurology, 2014. 261: p. 267-277. (IF: 4.483,中科院二區)
10. Jun Lou, Lie Huang, Aimei Wang, Yueyang Liu, Ruiping Cai, Weihong Li, Mingsheng Zhou*. Resistin-Induced Endoplasmic Reticulum Stress Contributes to the Impairment of Insulin Signaling in Endothelium, Frontiers in pharmacology, 2018, 9:1226. (IF: 3.845,中科院二區)
11. Tianyu Zhang, Chunfu Wu, Xiaowei Yang, Yueyang Liu, Hanlin Yang, Linlin Yuan, Yinglu liu, Shibo Sun, Jingyu Yang*, Pseudoginsenoside-F11 Protects against Transient Cerebral Ischemia Injury in Rats Involving Repressing Calcium Overload. Neuroscience, 2019, 411:86-104 (IF:3.056,中科院三區)
12. Xue Xue, JingYu Yang, Yi He, LiRong Wang, Ping Liu, LiSha Yu, GuoHua Bi, MingMing Zhu, Yueyang Liu, RongWu Xiang, XiaoTing Yang, XinYu Fan, XiaoMin Wang, Jia Qi, HongJie Zhang, Tuo Wei, Wei Cui, GuangLu Ge, ZhengXiong Xi*, ChunFuWu*, Xing-Jie Liang*. Aggregated single-walled carbon nanotubes attenuate the behavioural and neurochemical effects of methamphetamine in mice. Nat Nanotechnol, 2016, Jul;11(7):613-20. (IF: 38.986,,中科院一區Top)
13. Xi Wu, Xue Xue, Liuhui Wang, Wenjing Wang, Jian Han, Xiaoxue Sun, Haotian Zhang, Yueyang Liu, Xiaohang Che, Jingyu Yang*, Chunfu Wu*. Suppressing autophagy enhances disulfiram/copper-induced apoptosis in non-small cell lung cancer, European journal of pharmacology, 2018, 827: 1-12. (IF: 3.04,中科院二區)
14. 劉月陽,姚陽,周明生,缺血性腦卒中後的神經發生及其相關幹預藥物研究進展,國際藥學研究雜志,2020年05期,第331-336頁。
15. 劉月陽,成體海馬神經發生在藥物成瘾中的作用研究進展,國際藥學研究雜志,2020年9月,第47卷,第9期,第683-697頁。
申請專利情況:
1. 楊靜玉; 吳春福; 劉月陽,TFEB作為腦卒中生物标記物及治療靶點的應用,ZL201711482143.0,2017-12-29(已授權)。
2. 周明生; 劉月陽; 安德魯·維克托·沙利; 蔡仁治; 蔡瑞平; 車曉航,GHRH-A在制備防治缺血性腦梗塞藥物中的應用,CN201911026415.5,2019-10-26。
3. 周明生; 蔡瑞平; 安德魯·維克托·沙利; 蔡仁治; 劉月陽; 唐琪,GHRH-A在制備治療非酒精性脂肪性肝病藥物中的應用,CN201911026401.3,2019-10-26。
其他: