姓名:張文鶴
性别:女
籍貫:遼甯沈陽
聯系電話:17521679697
E-Mail:zhangwenhe306@163.com
個人主頁:
職稱/職務:副教授
通訊☯⚜☯:遼甯省本溪高新技術開發區華佗大街26号
郵政編碼:110072
學習/工作經曆:2012.09-2016.06 bevictor伟德 藥物制劑專業 學士
2016.09-2021.12 bevictor伟德 微生物與生化藥學專業 博士
(2019.04-2021.12于中國科學院上海有機化學研究所聯合培養)
2022.03至今 bevictor伟德 微生物與細胞生物學教研室 專任教師
研究方向:多種類型生物催化劑的開發、蛋白質工程改造與應用;藥物中間體(主要涉及手性中間體)綠色合成路線的設計;天然産物生物合成途徑相關功能酶的研究。
兼職情況:
科研/獲獎情況:用于鹵代芳雜環砌塊合成的黃素依賴型鹵化酶的挖掘與重塑,國家自然科學基金青年科學基金項目(82204219),項目負責人
教學/指導研究生情況:承擔本科生《微生物學與免疫學》、《微生物學實驗》、《免疫學實驗》、《細胞生物學實驗》課程。
發表論文/出版著作:
近五年發表參與SCI文章8篇,其中一區文章3篇,以第一作者發表文章3篇,以通訊作者參與發表文章2篇,按時間順序排列如下:
1. Hengyu Li,Wenhe Zhang,Changli Che,Huibin Wang,Yutian Jia,Xiao Gao,Xian Jia,Qin Bin,Song You.Rationally Engineering the Cofactor Specificity of LfSDR1 for Biocatalytic Synthesis of the Key Intermediate of Telotristat Ethyl. ChemCatChem,2022,(影響因子:5.497)
2.Jiaxiang Lv,Yaqi Ding, Chenming Huang , Lingling Guo , Jiali Fang , Xian Jia ,Wenhe Zhang, Song You,Bin Qin.Enzymes and Chemo-Enzymes Catalyzed Stereodivergent Synthesis.PharmaceuticalFronts,2022, 04(03):121-135.
3.Jiyang Guo,Xiao Gao,Dong Qian,Huibin Wang,Xian Jia,Wenhe Zhang, Bin Qin,Song You.Efficient synthesis of an apremilast precursor andchiral β-hydroxy sulfones via ketoreductasecatalyzedasymmetric reduction.Organic & Biomolecular Chemistry, 2022, 20(10): 2081-2085.(影響因子:3.89)
4.Wenhe Zhang, Fei Wang, Yilin Wang,Song You,HaixuePan,GongliTang.Identification and Characterization of Enzymes Catalyzing Early Steps inMiharamycin and Amipurimycin Biosynthesis.Organic Letters,2021, 23(22), 8761–8765.(影響因子:6.072)
5. Hengyu Li,Wenhe Zhang,Xianyan Jiang,Huibin Wang,Qi Wang,Jiajun Wang,Xian Jia,Bin Qin,Song You. Development of an Enzymatic Process for the Synthesis of the Key Intermediate of Telotristat Ethyl. Advanced Synthesis & Catalysis, 2021,363(2): 540-548.(影響因子:5.981)
6. Fei Wang,Wenhe Zhang, Juan Zhao, Wenjia Kang, Shengyang Wang, Biao Yu, Hai-Xue Pan,Gongli Tang. Characterization of Miharamycin Biosynthesis Reveals a Hybrid NRPS–PKS to Synthesize High-Carbon Sugar from a Complex Nucleoside. Journal of the American Chemical Society, 2020,142(13): 5996-6000.(影響因子:16.383)
7.Wenhe Zhang, Tianhui Zhu, Hengyu Li, Fengyu Qin,Feiting Zhang, Rui Zhang,Xian Jia,Bin Qin,Song You. Key sites insight on the stereoselectivity of four mined aldo-keto reductases toward α-keto esters and halogen-substituted acetophenones[J]. Applied Microbiology and Biotechnology, 2019,103(1),6119–6128.(影響因子:5.56)
8. Fengyu Qin,Bin Qin, Wenhe Zhang, Yalin Liu, Xin Su, Tianhui Zhu, Jingping Ouyang, Jiyang Guo, Yuxin Li, Feiting Zhang, Jun Tang, Xian Jia,Song You.Discovery of a switch between Prelog and anti-Prelog reduction toward halogen-substituted acetophenones in short-chain dehydrogenase/reductases[J]. ACS Catalysis, 2018,8(7): 6012-6020.(影響因子:13.7)
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