姓名:趙曉雲
性别:女
籍貫:遼甯
聯系電話:18341400460
E-Mail:zhaoxiaoyun@syphu.edu.cn
個人主頁:
職稱/職務:副教授
通訊☯⚜☯:沈陽市沈河區文化路103号
郵政編碼:110001
學習/工作經曆:
(1)2001.8–至今,bevictor伟德,講師;
(2) 2003.9–2009.6,中國醫科大學,細胞生物學,博士;
(3) 1998.9–2001.6,中國醫科大學,微生物學,碩士;
(4) 1993.9–1997.7,沈陽師範學院,生物工程,學士
研究方向:
(1)腫瘤轉移與血腦屏障滲透性的關系;
(2)外泌體與核酸藥物載體
兼職情況:
遼甯省細胞生物學學會,創傷骨科專業委員會理事
科研/獲獎情況:
(1)遼甯省自然科學學術成果獎,The antitumor efficacy of docetaxel is enhanced by encapsulation in novel amphiphilic polymer cholesterol-coupled tocopheryl polyethylene glycol 1000 succinate micelles,2018.9.28
(田清菁;時佳;趙曉雲;邸東華;鄧意輝;宋豔志)
教學/指導研究生情況:
從事藥學細胞生物學、醫學細胞生物學和微生物學的本科教學工作。
發表論文/出版著作:
1. Exosome-based small RNA delivery:Progress and prospects
Mei Lu a,Haonan Xing a, Zhe Xun b, Tianzhi Yang c, Pingtian Ding a,Cuifang Cai a, Dongkai Wang a,*, Xiaoyun Zhao d,**.Asian Journal of Pharmaceutical Sciences. 13 ( 2018 ) 1 –11
2.Enhanced bioavailability of orally administered flurbiprofen by combined use of hydroxypropyl-cyclodextrin and poly(alkyl-cyanoacrylate) nanoparticles.Zhao X1,Li W,Luo Q,Zhang X,Eur J Drug Metab Pharmacokinet.2014 Mar;39(1):61-7.
3.Comparison of exosome-mimicking liposomes with conventional liposomes for intracellular delivery of siRNA.Lu M,Zhao X,Xing H,Xun Z,Zhu S,Lang L,Yang T,Cai C,Wang D,Ding P.Int J Pharm.2018 Oct 25;550(1-2):100-113.
4.The antitumor efficacy of docetaxel is enhanced by encapsulation in novel amphiphilic polymer cholesterol-coupled tocopheryl polyethylene glycol 1000 succinate micelles.Tian Q, Shi J, Zhao X, Di D, Deng Y, Song Y.Drug Deliv Transl Res.2017 Oct;7(5):642-653.
5.Cholesterol derivative-based liposomes for gemcitabine delivery: preparation, in vitro, and in vivo characterization.Li T, Chen L, Deng Y, Liu X, Zhao X, Cui Y, Shi J, Feng R, Song Y.Drug Dev Ind Pharm. 2017 Dec;43(12):2016-2025.
6.Preparation, characterization and pharmacokinetics evaluation of clarithromycin-loaded Eudragit(®) L-100 microspheres.Xu J, Li W, Liu Z, Li J, Zhao X, Li D, Guo S, Zhang X.Eur J Drug Metab Pharmacokinet. 2016 Jun;41(3):287-93
7.Improved thermal cycling durability and PCR compatibility of polymer coated quantum dot.Xun Z1,Zhao X,Guan Y.Nanotechnology.2013 Sep 6;24(35):355504.
8.A novel plasmid and SonoVue formulation plus ultrasound sonication for effective gene delivery in nude mice.Wang XL1,Zhao XY,Li S,Jia CJ,Jiang L,Shi TM,Ren WD.Life Sci.2013 Oct 11;93(16):536-42.
9.Elevated PLGF contributes to small-cell lung cancer brain metastasis.Li B1,Wang C,Zhang Y,Zhao XY,Huang B,Wu PF,Li Q,Li H,Liu YS,Cao LY,Dai WM,Fang WG,Shang DS,Cao L,Zhao WD,Chen YH.Oncogene.2013 Jun 13;32(24):2952-62. doi: 10.1038/onc.2012.313.
10.Clinical implications of REST and TUBB3 in ovarian cancer and its relationship to paclitaxelresistance.Gao S1,Zhao X,Lin B,Hu Z,Yan L,Gao J.Tumour Biol.2012 Oct;33(5):1759-65.
11.SHP-2 phosphatase promotes cervical cancer cell proliferation through inhibiting interferon-β production.Meng F1,Zhao X,Zhang S.J Obstet Gynaecol Res.2013 Jan;39(1):272-9.
12. Expression and significance of SHP-2 in human papillomavirus infected cervical cancer.Meng F1,Zhao X,Zhang S.J Huazhong Univ Sci Technolog Med Sci.2012 Apr;32(2):247-51. Epub 2012 Apr 20.
其他:
基金項目:
1.國家自然科學基金面上項目,81872822,PAAs類聚合物作為基因載體的構建策略的研究,2019/01-2022/12,參加;
2.青年科學基金,8170131389,針對腫瘤早期的基于單核細胞遞送唾液酸修飾脂質體重塑/清除M2型腫瘤相關巨噬細胞的靶向治療策略,2018/01-2020/12,參加;
3.國家自然科學基金青年基金,81302662,基于αβ靶點的抗阿爾茨海默症—天然玉蕊醇型三萜的發現及作用機制研究,2014/01-2016/12,參加;
4.國家自然科學基金面上項目,30973868,中藥芫花炮制前後物質基礎及抗腫瘤活性改變的相關研究,2010/01-2012/12,參加;
5.國家自然科學基金青年基金,30500277,Ibe-β蛋白介導大腸杆菌侵襲人腦微血管内皮細胞的機制研究,2006/01-2008/12,參加;
6.橫向課題(中國科學院金屬研究所),2009-0-4-029,褐藻多糖生物學活性初步研究,2009.04-2009.07,主持。
教材編寫:
全國高等醫藥院校藥學類規劃教材:
1.《藥學細胞生物學》,中國醫藥科技出版社,2006年
2.《藥學細胞生物學》,中國醫藥科技出版社,2015年